Alabama vs. LSU prediction, odds, time: Week 10 college football picks from proven model

A classic late-season SEC showdown carries major College Football Playoff weight when the No. 14 LSU Tigers host the No. 5 Alabama Crimson Tide. A win for either the Tigers (6-2, 3-2) or Crimson Tide (6-2, 4-2) strengthens its changes for a playoff bid, while a loss creates a steeper path with November still ahead. Alabama has dominated the head-to-head meetings, winning the last three by double-figures and 13 of the last 15 overall. Lane Kiffin, who was the offensive coordinator for the Tide under Nick Saban from 2014-16, is seeking his first win over Alabama as a head coach (0-5 career), while Kalen DeBoer is 2-0 against LSU. Star Alabama receiver Ryan Coleman-Williams is set to return after missing the past two games. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55:

Kickoff is set for 3:30 p.m. ET at Tiger Stadium in Baton Rouge, La. The Tigers are 6-point favorites, while the over/under is 53.5 in the latest Alabama vs. LSU odds. Before making any LSU vs. Alabama picks, check out the Alabama vs. LSU predictions from the SportsLine Projection Model. 

Alabama vs. LSU odds

Alabama vs. LSU spread

LSU -6

Alabama vs. LSU over/under

53.5 points

Alabama vs. LSU money line 

LSU -225, Alabama +195

Alabama vs. LSU picks

See picks at SportsLine

Alabama vs. LSU streaming 

Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10:

Top Alabama vs. LSU predictions

After simulating Alabama vs. LSU 10,000 times, SportsLine model is going Over 53.5 points at betting apps and the best college football betting sites. The Over has cashed in every Alabama victory, and in neither of its defeats. 

The Tigers feature one of the nation's most explosive offenses, scoring at 40.1 ppg. QB Sam Leavitt has been stead with 2,173 yards and 17 TDs. He'll face one of the premier defenses, thought the Tiger is better vs. the run than it is the pass, and LSU can throw it around with the best of them. Alabama counters with Keelon Russell, who's passed for 2,057 yards with 20 combined TDs. LSU has allowed 17 points or less in each win, and over 30 points in each loss. 

The computer projects the Over as the value side 52% of the time. See the model's spread and money-line picks at SportsLine.

How to make Alabama vs. LSU picks

In addition to going Over on the total, the model also says one side of the spread hits in well over 50% of simulations. You can only get the pick at SportsLine. 

So who wins LSU vs. Alabama, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that's on a 80-77 run on top-rated CFB picks, and find out.

Why you should trust SportsLine's model

SportsLine's model simulates every FBS game 10,000 times. It entered Week 10 on a 80-77 run on all top-rated college football picks at betting sites. 

Alabama vs. LSU picks from 10,000 simulations

Adam Thompson 2 min read

NFL trade buzz: Colts taking calls on Daniel Jones; one team makes sense John Breech 3 min read

Five under-the-radar MLB free agents who could make a big impact Mike Axisa 3 min read

Shedeur’s grin gives Saints all the bulletin board material they need Carter Bahns 2 min read

Lake eats his words after roasting Herbert’s ‘deli meat’ throws Brad Crawford 2 min read

Nebraska fires OC Holgorsen amid four-game losing streak Robby Kalland 1 min read

Luka drops 53 as his historic start leaves even Lakers legends behind Brad Botkin 5 min read

Mock trades that would make Steelers a real contender

Bryan DeArdo 4 min read

UConn takes down Michigan, puts college basketball on notice -- again Matt Norlander 7 min read

MLB rumors: Skubal market heating up, contenders eyeing Sato Mike Axisa 2 min read